Understanding the “Folate Trap”
Laura LewisWhy L-Methylfolate Needs Other Nutrients to Work Effectively
Many people think they’re covering all their folate needs when taking an L-methylfolate supplement. However, the reality is a bit more complex. L-methylfolate is an important form of folate in the body, especially for mental health, cellular health, and energy levels. But on its own, it might not be enough. Without the right supporting nutrients, L-methylfolate becomes “stuck” in a process we call the folate trap. In this blog, we’ll explore what the folate trap is. We explain why it happens, and how adding key vitamins can help you avoid it.
What is the Folate Trap?
The folate trap occurs when folate (in its active form, L-methylfolate) becomes unusable in the body due to insufficient levels of vitamin B12. This “trap” prevents folate from participating in crucial functions like creating new copies of DNA, supporting brain health, and aiding in red blood cell formation [1]. Even if your body has enough L-methylfolate, without B12, the body cannot utilize it properly. It can lead to symptoms of folate insufficiency despite adequate folate levels [1].
Below is a figure showing the necessary cofactors, enzymes, and methylators for healthy methylation. It shows where the folate trap can occur, why L-methylfolate is not functional without B12, and why homocysteine can build up when the trap occurs.
Why L-Methylfolate Needs Other Nutrients to Work Effectively
Many people think they’re covering all their folate needs when taking an L-methylfolate supplement. However, the reality is a bit more complex. L-methylfolate is an important form of folate in the body, especially for mental health, cellular health, and energy levels. But on its own, it might not be enough. Without the right supporting nutrients, L-methylfolate becomes “stuck” in a process we call the folate trap. In this blog, we’ll explore what the folate trap is. We explain why it happens, and how adding key vitamins can help you avoid it.
What is the Folate Trap?
The folate trap occurs when folate (in its active form, L-methylfolate) becomes unusable in the body due to insufficient levels of vitamin B12. This “trap” prevents folate from participating in crucial functions like creating new copies of DNA, supporting brain health, and aiding in red blood cell formation [1]. Even if your body has enough L-methylfolate, without B12, the body cannot utilize it properly. It can lead to symptoms of folate insufficiency despite adequate folate levels [1].
Below is a figure showing the necessary cofactors, enzymes, and methylators for healthy methylation. It shows where the folate trap can occur, why L-methylfolate is not functional without B12, and why homocysteine can build up when the trap occurs.
