The professional-strength form of L‑Methylfolate recommended by your doctor

If your doctor has told you that you need the activated form of folate, then MethylPro® is for you. Folate is a B vitamin that is necessary for healthy mood, cardiovascular function, and reproduction. It is essential for life and development, which is why pregnant women need to take it every day. Lately, there is more evidence showing that folate promotes brain health. But even if you eat folate every day, your body may desperately need this B vitamin.

Up to 50% of people don't have the enzyme that "turns on" (or activates) folate to the body's most useful form, L-methylfolate. This means that even if you take folic acid each day, your body may be unable to use it. This may mean you have the MTHFR gene mutation.

People who have this genetic mutation may have a nutritional deficiency of folate even though they are eating fortified foods, folate-rich foods, and taking over-the-counter vitamins. For nutritional support, doctors recommend that their patients take the active form of the vitamin known as L-methylfolate.

If you have the MTHFR gene mutation, you could benefit from MethylPro®. Learn more about methylenetetrahydrofolate reductase, or the MTHFR gene mutation.

What folate does in your body:

  • Makes neurotransmitters (mood chemicals) found in the brain
  • Lowers homocysteine, which supports heart health.
  • Makes the building blocks of DNA
  • Helps remove toxins from the body
  • Makes proteins

Why it may be recommended:

  • Low mood or low levels of neurotransmitters
  • High homocysteine
  • Poor nerve health
  • Uric acid excess
  • Structurally or functionally inefficient red blood cells
  • Neural tube defects
  • Poor pregnancy outcomes

Ask your physician if you could benefit from taking MethylPro®

MethylPro® is a pure, hypoallergenic, high-quality, professional-strength L-methylfolate supplement designed specifically to support a range of indications linked to folate deficiencies.

It is more affordable than other L-methylfolate products on the market. Metabolic Maintenance, the parent company to MethylPro, is a trusted source of high-quality vitamins and has been serving healthcare providers in the industry for more than four decades.

Folate and the Brain

Your brain needs healthy levels of chemical messengers, called neurotransmitters, to function well. L-methylfolate supports brain health by balancing mood-elevating neurotransmitters such as serotonin and dopamine. L-methylfolate is also involved in the production of melatonin, which is important for maintaining normal sleep patterns. Additionally, L-methylfolate helps produce epinephrine and norepinephrine, also known as adrenaline and noradrenaline, which are crucial for responding to stressful situations.

Healthy levels of brain neurotransmitters are necessary for normal:

  • Short-term memory
  • Concentration
  • Sleep
  • Mood stability
  • Motivation and desire
  • Appetite control
  • Stress response

Folate plays an additional role in brain health via its role in the metabolism of homocysteine. Long term cognitive health is intimately tied with maintaining heart and small blood vessel health. Normal homocysteine levels support normal inflammatory balance in the brain and cardiovascular system.

Folate and the Body

Homocysteine and Cardiovascular Health

Maintaining cardiovascular health is a long term balancing act that in part requires maintaining a healthy inflammatory response. Maintaining normal homocysteine levels supports healthy inflammatory balance in the cardiovascular system. L-Methylfolate helps regulate homocysteine levels. It takes part in the biochemical pathway that recycles homocysteine to its parent molecule (methionine), preventing it from building up in the body. Adequate folate intake supports normal levels of homocysteine in the blood, supporting a healthy inflammatory response and functional blood vasculature.

Those with certain MTHFR gene polymorphisms are more likely to have elevated homocysteine, although this is not always the case. L-Methylfolate and its cofactors, vitamins B6 and B12, aid by optimizing homocysteine metabolism, preventing its buildup in the blood.

Even if you have normal homocysteine levels presently, your doctor may recommend L-Methylfolate to maintain healthy levels. L-Methylfolate also supports heart health by enhancing blood flow and increasing nitric oxide in the cardiovascular system. Nitric oxide is a beneficial chemical produced by your body that relaxes blood vessels, allowing smoother blood flow.

Uric Acid

Proper uric acid metabolism is needed for joint and urinary comfort. Folate rich foods or folate supplementation can provide this essential vitamin for normal uric acid metabolism to support joint health.

Reproductive Health

Folate is essential for the normal development of the neural tube, brain, and spinal cord. The Centers for Disease Control recommends that all women of childbearing age take folic acid daily to support healthy neural tube development. Women who maintain a healthful diet with adequate folate throughout their childbearing years may support the development of the brain and spinal cord in their children.

In addition, folate contributes to fertility and healthy pregnancy via its action on the metabolism of homocysteine. Homocysteine levels can be influenced by MTHFR status. L-methylfolate provides folate in a form that bypasses any slowed conversion of folate making it a universally bioavailable folate support for any MTHFR presentation. 

Sources of folate include fruits, vegetables, whole grain products, fortified cereals, and dietary supplements. Even with fortified products, some women may not get enough folate. L-Methylfolate is an excellent addition to a prenatal health plan because it is the most useful form of folate for the human body.


Manufacturing Process

We manufacture our supplements at our NSF GMP certified facility in Sisters, Oregon, adhering to stringent quality and manufacturing standards that go above and beyond FDA requirements.

Product Testing

Rigorous testing procedures are followed, including third-party testing for contaminants, potency, and quality. Upon receipt, all goods are examined and all products with a corresponding Certificate of Analysis are verified. Product is then moved to our Quality Assurance department, where raw material is tested for micros (bacterial colony count, yeast/mold, E. coli, coliforms), metals (arsenic, cadmium, lead, and mercury), as well as identification. All herb raw materials, soft gels and capsules are tested for Salmonella. Finished goods are again tested for micros and gluten prior to bottling.

Use of Fillers

Our products are free from wheat, gluten, nuts, egg, dairy, preservatives, or hydrogenated oils, unless specifically noted on the label. Our products contain no added coatings, excipients, binders, fillers, shellacs, artificial colors, artificial flavors, or fragrances. We do not use magnesium stearate, preservatives, BHA or BHT in our products, reflecting our commitment to clean, effective, allergy-free supplements.

Supplement Consumption

Most supplements are best taken with meals. Specific instructions are included on product labels.

Pregnancy and Lactation

MethylPro does not make recommendations concerning the use of products during pregnancy or lactation. Consult your healthcare practitioner regarding supplement use during pregnancy or lactation.

Choosing Supplements

Discuss with your healthcare provider to determine the best product for your needs.

Storage Recommendations

Store supplements in a cool, dry place with stable temperature and low light.

Capsule Source

Our vegetarian cellulose capsules are derived from sustainable, pesticide-free Southern Pine.

Ingredient Sourcing

We base our selection of ingredients on purity, quality, bioavailability, and ethical sourcing. We only purchase raw materials from proven industry leaders, including the finest suppliers from the U.S., France, Japan, and Italy. We test all raw ingredients using independent, certified laboratories. Ingredient suppliers must meet rigorous testing and quality criteria to qualify as a MethylPro supplier.

Do your products contain artificial ingredients or common food allergens like gluten and dairy?

Our products are free from wheat, gluten, nuts, egg, dairy, preservatives, or hydrogenated oils. Our products contain no added coatings, excipients, binders, fillers, shellacs, artificial colors, artificial flavors, or fragrances. We do not use magnesium stearate, preservatives, microcrystalline cellulose (MCC), silicon dioxide, BHA or BHT in our products, reflecting our commitment to clean, effective, allergy-free supplements.

Vegan and Allergen Information

Most products are vegan, with a few exceptions. Our products are mostly allergen-free, with clear labeling on exceptions.